1189363-91-4

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 202286-29-1 4-oxo-1-phenyl-4,5,6,7-tetrahydroisoindole 

Downstream Products

• 1189364-06-4 8-(p-methoxybenzyl)-7-phenyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline 
• 1575822-11-5 5-(hydroxymethylidene)-2-(4-methoxybenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one 
• 1575821-94-1 8-(4-methoxybenzyl)-N,7-diphenyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazolin-2-amine 
• 1575821-80-5 8-(4-methoxybenzyl)-7-phenyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazolin-2-amine 
• 1575821-67-8 8-(4-methoxybenzyl)-7-phenyl-3,5,6,8-tetrahydro-2H-pyrrolo[3,4-h]quinazolin-2-one 
• 1575822-00-2 5-[(diethylamino)methylidene]-2-(4-methoxybenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one 

Relevant academic research and scientific papers

NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES

The present invention relates to compounds having a tetracyclic system and the use thereof as new therapeutic agents in the treatment of acute myeloid leukemia (AML), preferably in FLT3/ITD hemizygote patients resistant to conventional therapies. The invention also relates to 5,7-dihydro-4H-[1,3]thiazolo[4,5-e]isoindol-2-amine compounds useful as intermediates for the synthesis of tetracyclic imidazo[2',1':2,3][1,3]thiazolo[4,5-e]isoindole compounds.

Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors

A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative activity of the new compounds on the full NCI human tumor cell line panel highlighted several com

Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

A new series of pyrrolo[3,4-h]quinazolines was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular cytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI50 values reaching the low micromolar level (1.3-19.8 μM). These compounds were able to induce cell death mainly by apoptosis through a mitochondrial dependent pathway. Selected compounds showed antimitotic activity and a reduction of tubulin polymerization in a concentration-dependent manner. Moreover, they showed anti-angiogenic properties since reduced in vitro endothelial cell migration and disrupted HUVEC capillary-like tube network in Matrigel.

Synthesis of the new ring system 6,8-dihydro-5H-pyrrolo[3,4-h]quinazoline

A convenient synthesis of the pyrrolo[3,4-h]quinazoline ring system is reported. Our synthetic approach consisted of the annelation of a pyrimidine ring to an isoindole moiety using tetrahydroisoindole-4-ones as building blocks. The antiproliferative activity of the new compounds was investigated and one of them showed antitumor activity against all the 59 tested cell lines at micromolar concentrations (1.46-18.4 μM).