1575822-00-2

Upstream product

• 202286-29-1 4-oxo-1-phenyl-4,5,6,7-tetrahydroisoindole 
• 1575822-11-5 5-(hydroxymethylidene)-2-(4-methoxybenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one 
• 109-89-7 diethylamine 
• 824-94-2 p-methoxybenzyl chloride 
• 1189363-91-4 2-(4-methoxybenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one 

Downstream Products

• 1575821-94-1 8-(4-methoxybenzyl)-N,7-diphenyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazolin-2-amine 
• 1575821-80-5 8-(4-methoxybenzyl)-7-phenyl-6,8-dihydro-5H-pyrrolo[3,4-h]quinazolin-2-amine 

Relevant academic research and scientific papers

Synthesis of a new class of pyrrolo[3,4-h]quinazolines with antimitotic activity

A new series of pyrrolo[3,4-h]quinazolines was conveniently prepared with a broad substitution pattern. A large number of derivatives was obtained and the cellular cytotoxicity was evaluated in vitro against 5 different human tumor cell lines with GI50 values reaching the low micromolar level (1.3-19.8 μM). These compounds were able to induce cell death mainly by apoptosis through a mitochondrial dependent pathway. Selected compounds showed antimitotic activity and a reduction of tubulin polymerization in a concentration-dependent manner. Moreover, they showed anti-angiogenic properties since reduced in vitro endothelial cell migration and disrupted HUVEC capillary-like tube network in Matrigel.