1189559-01-0Relevant academic research and scientific papers
Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents
Shao, Hao,Shi, Shenhua,Foley, David W.,Lam, Frankie,Abbas, Abdullah Y.,Liu, Xiangrui,Huang, Shiliang,Jiang, Xiangrui,Baharin, Nadiah,Fischer, Peter M.,Wang, Shudong
, p. 447 - 455 (2013/11/19)
A series of 2,4,5-trisubstituted pyrimidines have been synthesised and characterised, which exhibited potent CDK inhibition and anti-proliferative activities. The structure-activity relationship is analysed and a rational for CDK9 selectivity is discussed
PYRIMIDINES, TRIAZINES AND THEIR USE AS PHARMACEUTICAL AGENTS
-
Page/Page column 33, (2009/10/22)
A compound of formula (I) and its pharmaceutically acceptable salts or solvates and physiologically hydrolysable, solubilising or immobilisable derivatives wherein: Ar is a 5-membered heteroaryl ring wherein X1 and X2 are one or two
