22184-97-0

Basic information

• Product Name: 3-(MORPHOLINOSULFONYL)ANILINE
• Synonyms: TIMTEC-BB SBB005404;AKOS B000463;AKOS BBS-00006409;3-(MORPHOLINE-4-SULFONYL)-ANILINE;3-(MORPHOLINE-4-SULFONYL)-PHENYLAMINE;3-(MORPHOLIN-4-YLSULFONYL)ANILINE;3-(MORPHOLINOSULFONYL)ANILINE;3-(MORPHOLINOSULPHONYL)ANILINE
• CAS NO: 22184-97-0
• Molecular Formula: C₁₀H₁₄N₂O₃S
• Molecular Weight: 242.29
• Product Categories: Amines;blocks;Sulfonamides
• Mol File: 22184-97-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 132 °C
• Boiling Point: 456.6 °C at 760 mmHg
• Flash Point: 229.9 °C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 1.6E-08mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• PKA: 3.29±0.10(Predicted)
• CAS DataBase Reference: 3-(MORPHOLINOSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(MORPHOLINOSULFONYL)ANILINE(22184-97-0)
• EPA Substance Registry System: 3-(MORPHOLINOSULFONYL)ANILINE(22184-97-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22184-97-0(Hazardous Substances Data)

Usage

General Description

3-(Morpholinosulfonyl)aniline is a chemical compound with the molecular formula C10H13NO3S. It is often used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals. 3-(MORPHOLINOSULFONYL)ANILINE is a white to off-white solid that is soluble in organic solvents such as methanol and ethanol. It has a molecular weight of 235.28 g/mol and a melting point of 108-110°C. 3-(Morpholinosulfonyl)aniline is known for its use in the preparation of various organic compounds and serves as a key building block in the chemical industry.

InChI:InChI=1/C10H14N2O3S/c11-9-2-1-3-10(8-9)16(13,14)12-4-6-15-7-5-12/h1-3,8H,4-7,11H2

Upstream product

• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 91619-33-9 4-(3-nitrophenylsulfonyl)morpholine 

Downstream Products

• 870781-16-1 1-(3-(morpholinosulfonyl)phenyl)guanidine 
• 1189559-01-0 4-(4-methyl-2-(methylamino)thiazol-5-yl)-2-((3(morpholinosulfonyl)phenyl)amino)pyrimidine-5-carbonitrile 
• 1403818-84-7 N-(3-(morpholinosulfonyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-7-amine 
• 1272003-81-2 C₁₈H₁₈N₄O₄S 
• 379255-30-8 2-chloro-N-[3-(morpholin-4-ylsulfonyl)phenyl]acetamide 
• 1019851-71-8 C₁₇H₂₀N₂O₃S 
• 1272354-30-9 2-chloro-N-(3-(morpholinosulfonyl)phenyl)-5-phenylquinazolin-4-amine 
• 1272354-83-2 N-(3-(morpholinosulfonyl)phenyl)-5-phenyl-2-(pyrimidin-5-yl)quinazolin-4-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS

Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N′-diaryl urea inhibitors of soluble epoxide hydrolase

The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N′-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.

SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS

The present invention is directed to substituted 2-arylmethylene-N-aryl-N'-aryl-malonamides and analogs thereof. The present invention also relates to the discovery that the compounds are activators of caspases and inducers of apoptosis. Therefore, the activators os caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of anormal cells occurs.