118964-37-7

Upstream product

• 108-24-7 acetic anhydride 
• 55735-86-9 3,5-O-dibenzyloxy-1,2-O-isorpopylidene-α-D-ribofuranose 
• 33019-63-5 (2R,3R,4R,5R)-2-benzyloxymethyl-3,4-isopropylidenedioxy-5-methoxytetrahydrofuran 
• 100-39-0 benzyl bromide 
• 4099-85-8 ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 

Downstream Products

• 118964-38-8 Acetic acid (2R,3R,4R,5S)-4-acetoxy-2-benzyloxymethyl-5-chloro-tetrahydro-furan-3-yl ester 
• 118964-42-4 (2R,3R,4R,5R)-3-Allyloxy-5-((S)-5-allyloxy-2,3,4-tris-benzyloxy-pentyloxy)-4-benzyloxy-2-benzyloxymethyl-tetrahydro-furan 
• 118964-41-3 Acetic acid (2R,3R,4R,5R)-4-allyloxy-2-((S)-5-allyloxy-2,3,4-tris-benzyloxy-pentyloxy)-5-benzyloxymethyl-tetrahydro-furan-3-yl ester 
• 118964-52-6 (2R,3R,4S,5R)-4-Allyloxy-2-((S)-5-allyloxy-2,3,4-tris-benzyloxy-pentyloxy)-5-benzyloxymethyl-tetrahydro-furan-3-ol 
• 118964-43-5 (2R,3R,4R,5R)-4-Benzyloxy-2-benzyloxymethyl-5-((S)-2,3,4-tris-benzyloxy-5-hydroxy-pentyloxy)-tetrahydro-furan-3-ol 
• 118964-51-5 Acetic acid (2S,3R,4R,5R)-4-allyloxy-5-benzyloxymethyl-2-chloro-tetrahydro-furan-3-yl ester 
• 118964-40-2 (3aR,5R,6R,6aR)-6-Allyloxy-5-benzyloxymethyl-2-methoxy-2-methyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 118964-39-9 Acetic acid (3aR,5R,6R,6aR)-5-benzyloxymethyl-2-methoxy-2-methyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 

Relevant academic research and scientific papers

Synthesis of benzimidazole nucleosides and their anticancer activity

An efficient route for the synthesis of benzimidazole nucleosides 1–8 from readily available D-glucose via 3,5-dihydroxy-1,2-O-isopropylidene-α-D-ribofuranose and 3-azido-3-deoxy-1,2-O-isopropylidene-α-D-xylofuranose intermediates has been adopted. Ribofuranosyl nucleosides 1–4 with different benzimidazole bases, and 3?-deoxy-3?-azido-ribofuranosyl nucleosides 5–8, as another series, were obtained. All these newly synthesized analogs were evaluated for anticancer activity using MDA-MB-231 cell line. Among the differently substituted derivatives, 3?-azide substituted nucleosides (5–8) are more potent compared to ribofuranosyl analogs 1–4. The C-3?-azido analog 8 having anthryl group at 2-position of nucleobase show almost similar potency as that of standard etoposide.

A NEW APPROACH TO THE SYNTHESIS OF A DIMERIC FRAGMENT OF THE CAPSULAR POLYSACCHARIDE OF HAEMOPHILUS INFLUENZAE type b

The synthesis of the monomeric fragment of the Haemophilus influenzae type b (HIb) polysaccharide starting from orthoacetate 7 is described.The construction of the dimer is also reported.