118970-38-0Relevant academic research and scientific papers
Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids
Andres, Jose M.,Martinez, Maria A.,Pedrosa, Rafael,Perez-Encabo, Alfonso
, p. 347 - 353 (2007/10/03)
Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.
Unique Stereocontrol in Europium (III)-Catalyzed Cyanosilylation of chiral α-Alkoxy and α-Amino Aldehydes
Gu, Jin-Hua,Okamoto, Mikako,Terada, Masahiro,Mikami, Koichi,Nakai, Takeshi
, p. 1169 - 1172 (2007/10/02)
The Eu(III)-catalyzed cyanosilylations of chiral α-alkoxy and α-amino aldehydes are shown to exhibit syn diastereofacial selection, the degree increasing with an increase in steric bulk of the alkyl chain in the aldehydes.The mechanism of this catalytic p
STEREOSELECTIVE CYANOHYDRIN-FORMING REACTIONS OF CHIRAL α-AMINO ALDEHYDES
Reetz, M. T.,Drewes, M. W.,Harms, K.,Reif, W.
, p. 3295 - 3298 (2007/10/02)
The Lewis acid mediated cyanohydrin-forming addition of Me3SiCN to optically active α-dibenzylamino aldehydes 2 occurs stereoselectively.Chelation controlled adducts 3 result if MgBr2 or TiCl4 is used, whereas the diastereomers 4 are obtained upon employi
