118975-80-7Relevant academic research and scientific papers
Beta-lactams synthesis using a metal compound as catalyst
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, (2008/06/13)
Trans-β-lactams are prepared by the reaction of a glycine alkyl ester and an imine, in the presence of an alkali metal base and a metal compound catalyst.
STEREOSELECTIVE ONE-POT SYNTHESES OF TRANS-3-AMINO-β-LACTAMS FROM ZINC ENOLATES OF N-PROTECTED α-AMINOACID ESTERS AND IMINES
Steen, Fred H. van der,Jastrzebski, Johann T.B.H.,Koten, Gerard van
, p. 2467 - 2470 (2007/10/02)
A new one-pot synthesis of 3-amino-β-lactams that is based on the condensation of simple imines with zinc enolates of disilyl protected glycine esters is reported.Isolated yields are high and a trans-selectivity is observed.
