118976-15-1Relevant academic research and scientific papers
Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C
Carpenter, Colleen,Sorenson, Roderick J.,Jin, Yafei,Klossowski, Szymon,Cierpicki, Tomasz,Gnegy, Margaret,Showalter, Hollis D.
, p. 5495 - 5504 (2016/10/24)
The clinical selective estrogen receptor modulator tamoxifen is also a modest inhibitor of protein kinase C, a target implicated in several untreatable brain diseases such as amphetamine abuse. This inhibition and tamoxifen's ability to cross the blood br
Effect of Triphenylacrylonitrile Derivatives on Estradiol-Receptor Binding and on Human Breast Cancer Cell Growth
Bignon, Eric,Pons, Michel,Paulet, Andre Crastes de,Dore, Jean-Christophe,Gilbert, Jacques,et al.
, p. 2092 - 2103 (2007/10/02)
In a study of a series of 26 triphenylacrylonitrile derivatives (TPEs), we investigated the influence of several possibly interrelated factors on the proliferation of human breast cancer cell lines. (1) Chemical substituents: the test compounds were for t
