1189804-53-2

Upstream product

• 1189804-50-9 (R)-4-benzyl-3-((2R,3S)-5-(tert-butyldiphenylsilyloxy)-2-methyl-3-(triethylsilyloxy)pentanoyl)oxazolidin-2-one 
• 112-55-0 1-dodecylthiol 

Downstream Products

• 1189804-55-4 (7S,8R)-13-(allyloxy)-14-(3-(benzyloxy)-1-methoxypropyl)-16,16-diethyl-2,2,8,12,12-pentamethyl-3,3-diphenyl-7-(triethylsilyloxy)-4,15-dioxa-3,16-disilaoctadec-10-yn-9-one 
• 1253891-02-9 (6R,7R,12R,13R)-13-((S)-2-((4S,5S,6R)-6-((R)-but-3-en-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)-1-methoxyethyl)-15,15-diethyl-2,2,7,11,11-pentamethyl-3,3-diphenyl-6,12-bis(triethylsilyloxy)-4,14-dioxa-3,15-disilaheptadec-9-yn-8-one 

Relevant academic research and scientific papers

Towards the total synthesis of Calyculin C: preparation of the C13-C25 spirocyclic core

A stereoselective synthesis of the C13-C25 of Calyculin C is described. Key steps involve the coupling of a terminal acetylene with a thiol ester and subsequent spirocyclisation using a double intramolecular hetero-Michael addition.