1189889-44-8 Usage
Description
Telmisartan-d3 is a chemical compound that serves as an internal standard for the quantification of telmisartan by gas chromatography (GC) or liquid chromatography (LC) mass spectrometry (MS). It is a nonpeptide angiotensin II receptor antagonist, which selectively and insurmountably inhibits the AT II receptor subtype AT1. Additionally, it acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), contributing to its blood pressure-lowering effects. Telmisartan-d3 is an off-white crystalline solid.
Uses
Used in Pharmaceutical Industry:
Telmisartan-d3 is used as an internal standard for the quantification of telmisartan by GCor LC-MS. This application is crucial for ensuring accurate and reliable measurements of telmisartan levels in various pharmaceutical formulations and research studies.
Used in Hypertension Treatment:
As a nonpeptide angiotensin II receptor antagonist, telmisartan-d3 plays a role in the treatment of hypertension. It selectively inhibits the AT II receptor subtype AT1, which helps in reducing blood pressure in various animal models of hypertension.
Used in Cardiovascular and Renal Protection:
Telmisartan-d3, through its action as a partial agonist of PPARγ, contributes to the reduction of cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis. This makes it a valuable compound in the prevention and treatment of cardiovascular and renal diseases.
Used in Research and Development:
Telmisartan-d3 is used as a research tool in the development of new drugs and therapies targeting the renin-angiotensin system. Its role as an internal standard allows for precise measurements and analysis of telmisartan's effects in various experimental settings.
Check Digit Verification of cas no
The CAS Registry Mumber 1189889-44-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,8,8 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1189889-44:
(9*1)+(8*1)+(7*8)+(6*9)+(5*8)+(4*8)+(3*9)+(2*4)+(1*4)=238
238 % 10 = 8
So 1189889-44-8 is a valid CAS Registry Number.
1189889-44-8Relevant articles and documents
Deuterated methyl telmisartan as well as preparation method and application thereof
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, (2018/08/28)
The invention belongs to the field of organic and pharmaceutical synthesis, and discloses deuterated methyl telmisartan as well as a preparation method and application thereof. The method adopts 3-methyl-4-nitrobenzoic acid as a raw material, adopts deute
