1189889-44-8

Usage

Uses

Used in Pharmaceutical Industry:
Telmisartan-d3 is used as an internal standard for the quantification of telmisartan by GCor LC-MS. This application is crucial for ensuring accurate and reliable measurements of telmisartan levels in various pharmaceutical formulations and research studies.
Used in Hypertension Treatment:
As a nonpeptide angiotensin II receptor antagonist, telmisartan-d3 plays a role in the treatment of hypertension. It selectively inhibits the AT II receptor subtype AT1, which helps in reducing blood pressure in various animal models of hypertension.
Used in Cardiovascular and Renal Protection:
Telmisartan-d3, through its action as a partial agonist of PPARγ, contributes to the reduction of cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis. This makes it a valuable compound in the prevention and treatment of cardiovascular and renal diseases.
Used in Research and Development:
Telmisartan-d3 is used as a research tool in the development of new drugs and therapies targeting the renin-angiotensin system. Its role as an internal standard allows for precise measurements and analysis of telmisartan's effects in various experimental settings.

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Relevant academic research and scientific papers

Deuterated methyl telmisartan as well as preparation method and application thereof

The invention belongs to the field of organic and pharmaceutical synthesis, and discloses deuterated methyl telmisartan as well as a preparation method and application thereof. The method adopts 3-methyl-4-nitrobenzoic acid as a raw material, adopts deute

C13 deuterated methyl telmisartan and preparation method and application thereof

The invention belongs to the field of organic medicinal synthesis, and discloses C13 deuterated methyl telmisartan and a preparation method and application thereof. According to the preparation method, with C13 deuterated methanol as a C13 deuterated raw material, the C13 deuterated telmisartan is synthesized through a four-step reaction. The preparation method comprises the following steps: iodizing the C13 deuterated methanol to obtain C13 deuterated iodomethane; performing a substitution reaction on the C13 deuterated iodomethane and a compound (III) to obtain a compound (IV); performing aSuzuki coupling reaction on the compound (IV) and 2-boro methylbenzoate to obtain a compound (V); performing esterolysis on the compound (V) under an alkaline condition to obtain the C13 deuterated telmisartan. The preparation method is easy and convenient to operate; by the preparation method, a C13 deuterated reagent is saved, the cost is low and purification is easy; a purified product is obtained after rapid preparation and chromatographic purification. A standard deuterated telmisartan substance prepared by the preparation method provided by the invention is high in purity and stable in chemical properties, and can be applied to preparation of an analytical standard substance.