118989-14-3Relevant academic research and scientific papers
Synthesis and biological evaluation of β-ionone oriented proapoptosis agents by enhancing the ROS generation
Cao, Yu-Xin,Liu, Guo-Yun,Mu, Wen-Wen,Yang, Jie
, (2020)
β-ionone, a cyclic terpenoid compound present in many fruits, has been showed a broad spectrum of biological activities. In this paper, we synthesized a panel of β-ionone derivatives and tested their anti-proliferation activity on cancer cell by the MTT a
Beta-ionone substituted curcumin analogue as well as preparation method and application of beta-ionone substituted curcumin analogue
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Paragraph 0025; 0026-0028; 0030-0032; 0039; 0040; 0041, (2017/07/12)
The invention discloses a beta-ionone substituted curcumin analogue as well as a preparation method and application of the beta-ionone substituted curcumin analogue. The structure of the curcumin analogue is shown as a formula (I), wherein R is substituted or unsubstituted phenyl and substituted or unsubstituted heteroaryl; a substituent group on the phenyl or the heteroaryl is selected from one or more of alkyl, alkoxyl, halogen, nitryl and dialkyl amine. A pharmacological effect test proves that a beta-ionone segment is introduced into a parent structure of curcumin, so that the anti-inflammatory activity of the compound can be remarkably improved, levels of TNF-alpha (Tumor Necrosis Factor-alpha) and IL-6 (Interleukin-6) are reduced and the probability of occurrence of infectious shock is reduced. (The formula (I) is shown in the description.).
