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118994-90-4

118994-90-4

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118994-90-4 Usage

Uses

Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported.

Check Digit Verification of cas no

The CAS Registry Mumber 118994-90-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,9,9 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 118994-90:
(8*1)+(7*1)+(6*8)+(5*9)+(4*9)+(3*4)+(2*9)+(1*0)=174
174 % 10 = 4
So 118994-90-4 is a valid CAS Registry Number.
InChI:InChI=1/C4H3NO3/c6-4(7)3-1-5-2-8-3/h1-2H,(H,6,7)

118994-90-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (H30179)  Oxazole-5-carboxylic acid, 98+%   

  • 118994-90-4

  • 1g

  • 678.0CNY

  • Detail

  • Alfa Aesar

  • (H30179)  Oxazole-5-carboxylic acid, 98+%   

  • 118994-90-4

  • 5g

  • 1353.0CNY

  • Detail

  • Aldrich

  • (722111)  5-Oxazolecarboxylicacid  97%

  • 118994-90-4

  • 722111-500MG

  • 462.15CNY

  • Detail

118994-90-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Oxazole-5-carboxylic acid

1.2 Other means of identification

Product number -
Other names 1,3-oxazole-5-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118994-90-4 SDS

118994-90-4Relevant articles and documents

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

Bream, Robert N.,Clark, Hugh,Edney, Dean,Harsanyi, Antal,Hayler, John,Ironmonger, Alan,Mc Cleary, Nadine,Phillips, Natalie,Priestley, Catherine,Roberts, Alastair,Rushworth, Philip,Szeto, Peter,Webb, Michael R.,Wheelhouse, Katherine

, p. 529 - 540 (2021/03/01)

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

CHEMICAL COMPOUNDS

-

Page/Page column 49, (2018/03/06)

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

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