118994-90-4

Usage

Uses

Used in Pharmaceutical Industry:
OXAZOLE-5-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can contribute to the biological activity and pharmacological properties of the final drug product.
Used in Agrochemical Industry:
OXAZOLE-5-CARBOXYLIC ACID is also utilized as a building block in the development of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds.
Used in Organic Synthesis:
OXAZOLE-5-CARBOXYLIC ACID is employed as a versatile reactant in organic synthesis, particularly in decarboxylative cross-coupling reactions with aryl halides. This process allows for the formation of new chemical bonds and the creation of diverse molecular structures with potential applications in various industries.

InChI:InChI=1/C4H3NO3/c6-4(7)3-1-5-2-8-3/h1-2H,(H,6,7)

Upstream product

• 118994-89-1 oxazol-5-yl-carboxylic acid ethyl ester 

Downstream Products

• 1148157-04-3 C₂₈H₃₈N₄O₆ 
• 1174651-12-7 N-(3-bromo-4-(2-(pyrrolidin-1-yl)ethoxy)phenethyl)oxazole-5-carboxamide 
• 1346809-07-1 tert-butyl oxazol-5-ylcarbamate 

Relevant academic research and scientific papers

Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib

This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in a pilot plant on a multikilogram scale to deliver >100 kg of product.

Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A

A new variant of the intramolecular Diels-Alder oxazole (IMDAO) cycloaddition that provides direct access to 6-azaindoles was developed. The IMDAO reaction was applied in a total synthesis of the aminophenylpyrrole-derived alkaloid marinoquinoline A, also

CHEMICAL COMPOUNDS

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

PROCESSES TO MAKE INDAZOLE DERIVATIVES

The present invention provides novel processes for preparing compounds of formula (IV) and salts thereof, novel intermediates,and a novel salt and polymorph thereof.