119-23-3

Basic information

• Product Name: 1,4-DIETHOXY-2-NITROBENZENE
• Synonyms: 1,4-diethoxy-2-nitro-benzen;NITROHYDROQUINONE DIETHYL ETHER;HYDROQUINONE NITRODIETHYL ETHER;1,4-DIETHOXY-2-NITROBENZENE;2,5-DIETHOXYNITROBENZENE;1-NITRO-2,5-DIETHOXYBENZENE;2-Nitrohydroquinone, diethyl ether;1,4-Diethoxy-2-nitrobenzol
• CAS NO: 119-23-3
• Molecular Formula: C₁₀H₁₃NO₄
• Molecular Weight: 211.21
• EINECS: 204-308-8
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives
• Mol File: 119-23-3.mol

Chemical Properties

• Melting Point: 48-51 °C(lit.)
• Boiling Point: 169 °C13 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.2022 (estimate)
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.5310 (estimate)
• CAS DataBase Reference: 1,4-DIETHOXY-2-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIETHOXY-2-NITROBENZENE(119-23-3)
• EPA Substance Registry System: 1,4-DIETHOXY-2-NITROBENZENE(119-23-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-37/39
• WGK Germany: 2
• Hazardous Substances Data: 119-23-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Diethoxy-2-nitrobenzene is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Dye Industry:
In the dye industry, 1,4-Diethoxy-2-nitrobenzene is utilized as a precursor in the production of different types of dyes, enhancing the color spectrum available for various applications.
Used in Fragrance Industry:
1,4-DIETHOXY-2-NITROBENZENE is also employed as a starting material in the synthesis of fragrances, playing a role in creating a wide range of scents for the perfumery and cosmetics sectors.
However, due to its toxic nature, 1,4-Diethoxy-2-nitrobenzene poses risks if ingested, inhaled, or absorbed through the skin, potentially causing irritation to the respiratory system and skin. Moreover, it is considered an environmental hazard, being harmful to aquatic organisms and potentially leading to long-term effects on aquatic ecosystems. Therefore, its use requires careful handling and management to mitigate its potential toxicity and environmental impact.

InChI:InChI=1/C10H13NO4/c1-3-14-8-5-6-10(15-4-2)9(7-8)11(12)13/h5-7H,3-4H2,1-2H3

Upstream product

• 75-09-2 dichloromethane 
• 122-95-2 1,4-diethoxybenzene 
• 123-31-9 hydroquinone 

Downstream Products

• 90222-67-6 4-ethoxy-2-nitrophenol 
• 86-16-8 4-Nitro-2,5-diethoxy-morpholinbenzen 
• 115021-46-0 2-Morpholino-3,6-diethoxy-nitrobenzene 
• 7463-29-8 2,5-Diethoxy-acetanilid 
• 74127-06-3 4-Nitro-2,5-diethoxy-brombenzen 
• 94-85-9 2,5-diethoxyaniline 

Relevant articles and documents

Nitration method for aryl phenol or aryl ether derivative

The invention relates to a nitration method for an aryl phenol or aryl ether derivative. The method comprises the steps of stirring an aryl phenol or aryl ether compound, nitrate, trimethylchlorosilane (TMSCl) and a copper salt in an acetonitrile solution in air at room temperature, simultaneously, monitoring extent of reaction through a TLC dot plate, removing a solvent from a mixture by a rotaryevaporator after a substrate is consumed completely, and carrying out purification through a silica-gel column, thereby obtaining a nitroolefin derivative. Meanwhile, the selective mono-nitration orbis-nitration of the substrate can be achieved through controlling equivalent weight of the nitrate. Compared with the prior art, the nitration method disclosed by the invention has the advantages that the consumption of strong-acid substances is avoided, the reaction conditions are mild, the yield is high, the applicable range of the substrate is wide, reaction activity is free of obvious attenuation after an amplified reaction, and an excellent yield is still obtained, so that the method has an obvious industrial application value.

Direct nitration method of electron-enriched aromatic hydrocarbons

The invention discloses a direct nitration method of electron-enriched aromatic hydrocarbons, and belongs to the field of organic synthesis. The direct nitration method is a novel green free radical nitration method; aromatic hydrocarbons are taken as raw materials, acetonitrile, dichloromethane, chloroform, or acetone is taken as a reaction solvent, at room temperature conditions, the raw materials and green nitration reagent tert-butyl nitrite (TBN) are subjected to free radical nitration so as to obtain nitro-aromatic compounds. According to the direct nitration method, no metal is adoptedin reaction, tert-butyl nitrite is directly adopted in nitration reaction. Electron-donating groups such as OMe are introduced, the electron density of aromatic compounds is increased, the nitration reaction possibility is increased. The using amount of tert-butyl nitrite is reduced; only a product and tert-butyl alcohol are generated, environment pollution is reduced. The direct nitration methodis promising in application prospect in the field of nitro-aromatic compound synthesis, green nitration is realized, and a novel idea is provided for large-scale industrialized nitro-aromatic compoundproduction.