1190-53-0 Usage
Description
Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production via the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
Chemical Properties
White Solid
Originator
Silubin,Protochemie,Switz.
Uses
Different sources of media describe the Uses of 1190-53-0 differently. You can refer to the following data:
1. BuforMin Hydrochloride is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. BuforMin Hydrochloride has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.
2. Buformin, clinically used for diabetes mellitus, is known to improve resistance to insulin in patients. It suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.
Manufacturing Process
105.6 g of n-butylamine hydrochloride and 79.3 g of dicyandiamide were
ground intimately and mixed. The mixture was heated by means of an oil
bath, gradually with stirring, and after thirty minutes when the internal
temperature had reached 150°C, an exothermic reaction ensued with internal
pressure rising to 178°C. The reaction mixture was removed from the oil bath
until the internal temperature had fallen to 150°C and then heating was
resumed at 150°C for one hour. The cooled fusion mixture was dissolved in 3
liters of acetonitrile and on cooling n-butyl-biguanide hydrochloride precipitated.
Therapeutic Function
Antidiabetic
Check Digit Verification of cas no
The CAS Registry Mumber 1190-53-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1190-53:
(6*1)+(5*1)+(4*9)+(3*0)+(2*5)+(1*3)=60
60 % 10 = 0
So 1190-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H
1190-53-0Relevant articles and documents
Oral formulation comprising biguanide and an organic acid
-
, (2008/06/13)
An oral formulation comprising a biguanide and an organic acid has less unpleasant tastes such as bitterness and saltiness.
