119003-84-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 111060-66-3 L-dibenzylvalinal 
• 5804-85-3 diethylaluminium cyanide 

Downstream Products

• 123054-18-2 methyl N,N-dibenzyl-L-valinate 
• 1352134-26-9 Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn 
• 1352134-29-2 C₂HF₃O₂*C₂₄H₃₃F₆N₃O₄ 
• 1352134-30-5 Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn 
• 163071-70-3 (2R,3S)-2-Benzyl-3-dibenzylamino-4-methyl-pentanenitrile 
• 163071-55-4 (R)-3-Dibenzylamino-4-methyl-pentanenitrile 
• 123054-17-1 (2S)-2-(dibenzylamino)-3-methylbutanoyl cyanide 

Relevant academic research and scientific papers

Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent: A route to enantiopure β-amino-α-hydroxy acids

Chiral α-dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-β-dibenzylamino-α-hydroxycyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure β-amino-α-hydroxy acids.

Stereoselective synthesis of β-amino nitriles and 1,3-diamines

Chiral β-N,N-dibenzylamino nitriles Bn2NCH(R)CH2CN, prepared in enantiomerically pure form from a-amino acids, can e deprotonated and stereoselectively alkylated to afford β-amino nitriles Bn2NCH(R)CH(R')CN with two stereo

STEREOSELECTIVE CYANOHYDRIN-FORMING REACTIONS OF CHIRAL α-AMINO ALDEHYDES

The Lewis acid mediated cyanohydrin-forming addition of Me3SiCN to optically active α-dibenzylamino aldehydes 2 occurs stereoselectively.Chelation controlled adducts 3 result if MgBr2 or TiCl4 is used, whereas the diastereomers 4 are obtained upon employi