1190081-75-4Relevant academic research and scientific papers
An easy access to halogenated and non-halogenated spiro-hexadienones
Martins, Lucimara J.,Ferreira, Bruno R.V.,Almeida, Wanda P.,Lancellotti, Marcelo,Coelho, Fernando
, p. 5264 - 5267 (2014)
We describe an improved protocol for the synthesis of spiro-hexadienones from Morita-Baylis-Hillman adducts. Solvent modification and temperature resulted in a significant increase in the yield. This protocol was used to synthesize mono- and dibrominated spiro-hexadienones in good overall yields. This report is the first to describe the synthesis of halogenated spiro-hexadienones from Morita-Baylis-Hillman adducts.
Spirocyclohexadienones as an uncommon scaffold for acetylcholinesterase inhibitory activity
Almeida, Wanda P.,Coelho, Fernando,Gomes, Ralph C.,Sakata, Renata P.
, p. 373 - 382 (2019/07/12)
Background: The most important cause of dementia affecting elderly people is the Alzheimer’s disease (AD). Patients affected by this progressive and neurodegenerative disease have severe memory and cognitive function impairments. Some medicines used for t
Nájera oxime-derived palladacycles catalyze intermolecular Heck reaction with Morita-Baylis-Hillman adducts. An improved and highly efficient synthesis of α-benzyl-β-ketoesters
Ferreira, Bruno R.V.,Pirovani, Rodrigo V.,Souza-Filho, Luis G.,Coelho, Fernando
experimental part, p. 7712 - 7717 (2009/12/03)
An improved and highly efficient synthesis of several α-benzyl-β-ketoesters from Morita-Baylis-Hillman adducts is described. These adducts were used as substrates for an intermolecular Heck reaction catalyzed by a Na?jera oxime-derived palladacycles. These efficient catalytic conditions probed to be very selective providing only the corresponding functionalized β-ketoesters in high yield with no decarboxylation product. It seems that the method herein described is one of the most efficient for the synthesis of α-benzyl-β-ketoesters.
Highly functionalized spirocyclohexadienones from Morita-Baylis-Hillman adducts
Pirovani, Rodrigo V.,Ferreira, Bruno R. V.,Coelho, Fernando
scheme or table, p. 2333 - 2337 (2009/12/08)
Spirohexadienone is a structural moiety present in several biologically active natural products isolated both from terrestrial and marine natural sources. This structural moiety is commonly and strictly related to the biological properties exhibited by th
