119017-74-2

Upstream product

• 118989-01-8 N-(1'-t-butoxy-2'-butyl)-10-aza<6,3,0>bicycloundecane 
• 118989-07-4 N-(1'-hydroxy-2'-butyl)-10-aza-6,3,0-bicycloundecane 
• 118989-11-0 N-benzyl-10-aza<6.3.0>bicycloundecane 

Relevant academic research and scientific papers

Organocations in zeolite synthesis: Fused bicyclo [l.m.0] cations and the discovery of zeolite SSZ-48

A set of zeolite synthesis experiments is described where lattice substitution is varied in the context of the structure of particular structure-directing organocations (at times referred to as templates). In this particular series, the organocations are constructed as members of a fused bicyclo organonitrogen class of compounds, described as having ring construction [l.m.n], where n = 0. We show that these compounds can best be achieved from starting cyclic ketones that are converted to imines via a Beckman rearrangement reaction. A particular approach to the Beckmann reaction works best in our hands. In some instances isomeric organocations are made and separated. Often their use in zeolite synthesis led to different products. There is a high correlation for the space-filling details of the guest organocations and the type of crystalline host lattice developed in the synthesis. In one instance involving isomers of a decahydroquinoline derivative, a new zeolite, SSZ-48, is discovered and contains only one of the isomers. Characterization of the isomers and their use in the zeolites is followed by 13C MAS NMR analyses. Some details of the new zeolite are given and it is shown that a reasonable symmetry operation predicting a 14-ring zeolite could be generated under similar conditions to SSZ-48 (a 12-ring zeolite).

The Use of the β-Amino-Alcohol-N-Oxide Derivatives in the Synthesis of 2,3 or 4-Alkyl Substituted NH Pyrrolidines

Nonstabilized azomethine ylides generated from the various β-amino alcohols N-oxides 13, 17, 23 and 24 undergo cycloaddition reactions with unactivated alkenes to afford the corresponding pyrrolidines 14a-g, 18a-g, 25 und 27 in moderate to good yields.These compounds are precursors of NH pyrrolidines substituted in position 2, 3 or 4.

A 3+2 CYCLOADDITION ROUTE TO N-H PYRROLIDINES DEVOID OF ELECTRON-WITHDRAWING GROUPS

N-H pyrrolidines are obtained from intermolecular 3+2 cycloaddition reactions between nonactivated olefins and ylide generated from amine N-oxide 1 structurally designed in such a way as to allow easy dealkylation of the cycloadduct.