119018-29-0Relevant articles and documents
An Efficient and Practical Process for the Synthesis of Glimepiride
Tanwar, Dinesh Kumar,Surendrabhai, Vaghela Ravikumar,Gill, Manjinder Singh
, p. 2495 - 2498 (2017)
A novel and simple approach to the synthesis of glimepiride is reported. It involves the preparation of a carbamate of 3-ethyl-4-methyl-1 H -pyrrol-2(5 H)-one, followed by its reaction with 4-(2-aminoethyl)benzenesulfonamide to produce the intermediate sulfonamide. This sulfonamide, upon reaction with phenyl (trans -4-methylcyclohexyl)carbamate, gave glimepiride. This process avoids the use of phosgene, isocyanates, or chloroformates. Furthermore, sulfonation of the aryl group was eliminated, rendering the product free of the impurities reported in earlier processes.
Preparation method of glimepiride intermediate
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Paragraph 0022, (2019/10/01)
The invention relates to a preparation method of a glimepiride intermediate compound I, and belongs to the technical field of preparation of raw material medicines. The preparation method comprises the following steps: reacting a compound II with diphenyl carbonate under the catalysis of an alkali (referring to Synlett, 28(18), 2495-2498; 2017) to prepare a compound IX; and adding a compound IX and 4-(2-aminoethyl)benzenesulfonamide according to a ratio of 1:1, adding a weak acid, adding isopropanol, and performing heating for a refluxing reaction. The invention provides the preparation methodof the glimepiride intermediate with a high purity.
Preparation method of glimepiride intermediate as drug for promoting insulin secretion
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Paragraph 0005; 0017-0018, (2018/05/07)
The invention discloses a preparation method of a glimepiride intermediate as a drug for promoting insulin secretion. The chemical name of the glimepiride intermediate as the drug for promoting the insulin secretion is 2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-formamido) ethylbenzenesulfonamide; the method is used for preparing the glimepiride intermediate, the preparation process is concise, the synthetic route is short, the preparation efficiency is improved, glimepiride is conducive to being prepared in later period, the method is convenient for realizing industrialization, can be used for reducing the production cost and is suitable for large-batch production, and the new sought preparation method of the glimepiride intermediate is very meaningful for the economic technology of the glimepiride.