1190216-41-1

Upstream product

• 67-56-1 methanol 
• 35092-89-8 4-(methoxycarbonyl)-3-nitrobenzoic acid 
• 138569-08-1 Methyl 4-carbamoyl-3-nitrobenzene 

Downstream Products

• 1241915-77-4 methyl 4-carbamoyl-3-(2,2-difluoro-2-(4-fluorophenyl)acetamido)benzoate 
• 1362910-83-5 2-(difluoro(4-fluorophenyl)methyl)-N-(5-methyl-1H-pyrazol-3-yl)-7-(morpholinomethyl)quinazolin-4-amine 
• 1241915-80-9 methyl 2-(difluoro(4-fluorophenyl)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazoline-7-carboxylate 
• 1241915-79-6 methyl 4-chloro-2-(difluoro(4-fluorophenyl)methyl)quinazoline-7-carboxylate 
• 1241915-78-5 methyl 2-(difluoro-(4-fluorophenyl)methyl)-4-hydroxyquinazoline-7-carboxylate 
• 1241915-76-3 (2-(difluoro(4-fluorophenyl)methyl)-4-(5-methyl-1H-pyrazol-3-ylamino)quinazolin-7-yl)-methanol 

Relevant academic research and scientific papers

QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are quinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

7-CYCLYLQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF

Provided herein are 7-cyclylquinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase- mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of

JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF

Provided herein are quinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions. (I).