1190219-60-3

Upstream product

• 23592-74-7 2-acetylcarbazole 
• 98-09-9 benzenesulfonyl chloride 
• 1283747-18-1 2-benzenesulfonylamido-4'-acetylbiphenyl 
• 31477-49-3 1-(2'-aminobiphenyl-4-yl)ethanone 
• 615-36-1 2-bromoaniline 
• 149104-90-5 4-acetylphenylboronic acid 

Downstream Products

• 1190219-62-5 C₂₀H₁₄BrNO₃S 

Relevant academic research and scientific papers

Intramolecular oxidative C-N bond formation for the synthesis of carbazoles: Comparison of reactivity between the copper-catalyzed and metal-free conditions

New synthetic procedures for intramolecular oxidative C-N bond formation have been developed for the preparation of carbazoles starting from N-substituted amidobiphenyls under either Cu-catalyzed or metal-free conditions using hypervalent iodine(III) as an oxidant. Whereas iodobenzene diacetate or bis(trifluoroacetoxy)iodobenzene alone undergoes the reaction to provide carbazole products in moderate to low yields, combined use of copper(II) triflate and the iodine(III) species significantly improves the reaction efficiency, giving a more diverse range of products in good to excellent yields. On the basis of mechanistic studies including kinetic profile, isotope effects, and radical inhibition experiments, the copper species is proposed to catalytically activate the hypervalent iodine(III) oxidants. The synthetic utility of the present approach was nicely demonstrated in a direct synthesis of indolo[3,2-b]carbazole utilizing a double C-N bond formation.

Antiproliferative compounds and therapeutic uses thereof

Inhibitors of the oncogenic tyrosine kinase ALK and of the Bcr-Abl mutant T315I Bcr-Abl, such as a compound of formula (I): wherein Q, T, W, K, J, Y, X, Z are independently selected from C, N, S, O, provided that the corresponding rings are (hetero)aromatic; n = 0 or 1; q = 1 or 2; pharmaceutical compositions containing the same and their use for the treatment of hyper-proliferative diseases.