1190286-91-9Relevant academic research and scientific papers
Rhodium- and palladium-catalyzed hydroarylation of propargylic amines with arylboronic acids
Arcadi, Antonio,Aschi, Massimiliano,Chiarini, Marco,Ferrara, Giovanni,Marinelli, Fabio
supporting information; experimental part, p. 493 - 498 (2010/07/06)
The hydroarylation of 3-arylprop-2-yn-1-amine derivatives with arylboronic acids has been studied in the presence of rhodium or palladium catalysts. By using a rhodium-based catalytic system, β,γ-diarylallylamines were isolated in good yields. By contrast, the formation of the regiosomeric γ,γ-diar-ylallylamines was achieved by means of a palladium catalyst in the presence of acetic acid. The complementary regioselectivity displayed by these two processes is a consequence of different catalytic cycles, involving respectively carborhodation or hydropalladation of the coordinated alkyne as key steps. Calculated charge distributions in the π-complexes are in accord with the results obtained.
