1190333-83-5

Basic information

• Product Name: 5-(4-azidophenyl)-2-tert-butoxycarbonylaminoimidazole-1-carboxylic acid tert-butyl ester
• Synonyms: 5-(4-azidophenyl)-2-tert-butoxycarbonylaminoimidazole-1-carboxylic acid tert-butyl ester
• CAS NO: 1190333-83-5
• Molecular Weight: 400.437
• Mol File: 1190333-83-5.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-azidophenyl)-2-tert-butoxycarbonylaminoimidazole-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-azidophenyl)-2-tert-butoxycarbonylaminoimidazole-1-carboxylic acid tert-butyl ester(1190333-83-5)
• EPA Substance Registry System: 5-(4-azidophenyl)-2-tert-butoxycarbonylaminoimidazole-1-carboxylic acid tert-butyl ester(1190333-83-5)

Safety Data

• Hazardous Substances Data: 1190333-83-5(Hazardous Substances Data)

Upstream product

• 57018-46-9 4-azidophenacyl bromide 
• 14848-01-2 4-azidobenzoyl chloride 
• 6427-66-3 4-azidobenzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1190333-55-1 2-amino-5-(4-azidophenyl)imidazole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1190333-84-6 2-tert-butoxycarbonylamino-5-{4-[4-(4-pentylphenyl)-[1,2,3]triazol-1-yl]phenyl}imidazole-1-carboxylic acid tert-butyl ester 
• 1190333-87-9 2-tert-butoxycarbonylamino-5-{4-[4-(3,5-difluorophenyl)-[1,2,3]triazol-1-yl]phenyl}imidazole-1-carboxylic acid tert-butyl ester 
• 1190333-49-3 5-{4-[4-(3,5-difluorophenyl)-[1,2,3]triazol-1-yl]-phenyl}-1H-imidazol-2-ylamine hydrochloride 

Relevant articles and documents

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

The synthesis and biofilm inhibitory activity of a 30-member aryl amide 2-aminoimidazole library against the three biofilm forming Gram-negative bacteria Escherichia coli, Psuedomonas aeruginosa, and Acinetobacter baumannii is presented. The most active compound identified inhibits the formation of E. coli biofilms with an IC50 of 5.2 μM and was observed to be non-toxic to planktonic growth, demonstrating that analogues based on an aryl framework are viable options as biofilm inhibitors within the 2-aminoimidazole family.

INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES

Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.