1190439-43-0Relevant articles and documents
One-pot synthesis of 1,2,4-oxadiazoles from chalcogen amino acid derivatives under microwave irradiation
Wolf, Lucas,Mayer, Jo?o C.P.,Quoos, Natália,Sauer, André C.,Schwab, Ricardo S.,Rodrigues, Oscar E.D.,Dornelles, Luciano
, (2021)
A series of sulfur- and selenium-bearing, amino acid-derived 1,2,4-oxadiazoles were obtained by a simple procedure. The method consists of EDC-promoted coupling of chalcogen amino acid derivatives with arylamidoximes in acetone, followed by solvent removal and microwave irradiation in water medium. Influence of amidoxime substituents, of the chalcogen atom and of the amino acid side chain is discussed. The results showed this to be a fast, easy and effective method to obtain these compounds, with good functional-group tolerance, potentially favouring future applications in organic synthesis.
Efficient synthesis of modular amino acid derivatives containing selenium with pronounced GPx-like activity
Alberto, Eduardo E.,Soares, Letiere C.,Sudati, Jessie H.,Borges, Antonio C.A.,Rocha, Joao B.T.,Braga, Antonio L.
supporting information; experimental part, p. 4211 - 4214 (2011/02/22)
New chiral selenide- and diselenide amino acid derivatives have been synthesized. By a simple and efficient two-step route, these new compounds were obtained from inexpensive and commercially available L-amino acids. The products, with a highly modular ch
