119049-32-0

Upstream product

• 19172-47-5 Lawessons reagent 
• 964-65-8 piperazin-1-yl-(3,4,5,trimethoxy-phenyl)-methanone 

Downstream Products

• 123947-22-8 1-(7,8-dimethoxy-2,3-dihydro-1-benzoxepin-4-carbonyl)-4-(3,4,5-trimethoxythiobenzoyl)piperazine 

Relevant academic research and scientific papers

PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof

Platelet Activating Factor (PAF) antagonists which comprises the compounds of the formula (I): wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R1, R2 and R3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4--yl group are novel compounds and exhibit excellent PAF antagonism.

PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof

Platelet Activating Factor (PAF) antagonists which comprise the compounds of the formula (I): STR1 wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R1, R2 and R3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4-yl group are novel compounds and exhibit excellent PAF antagonism.

1,4-disubstituted piperazines (or homopiperazines) as platelet-activating factor antagonists

Novel 1,4-disubstituted piperazine compounds represented by the formula (I): STR1 wherein A is a condensed polycyclic hydrocarbon group; R is a phenyl group substituted with a lower alkoxy group; X is methylene group, carbonyl group or thiocarbonyl group; and m is 2 or 3, and their salts are useful as a platelet activating factor antagonist.