119055-79-7Relevant academic research and scientific papers
19,11 β-bridged steroids, their manufacture and pharmaceutical preparations containing them
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, (2008/06/13)
New 19,11β-bridged steroids of the general formula I STR1 where R1 stands for a methyl or ethyl radical, R2 for a hydrogen or chlorine atom or a C1 -C4 -alkyl radical, B and G, which are the same or different, respectively for a hydrogen atom, a C1 -C4 -alkyl radical or, together, for a second bond between the carbon atoms 6 and 7, B and R2 together for a methylene or an ethylene group, Z for the radical of a pentagonal or hexagonal ring, which is possibly substituted and possibly unsaturated, V stands for a possibly substituted carbocyclic or heterocyclic aryl radical, the ring A for STR2 M and N together meaning a second bond or M a hydrogen atom and N a hydroxy group, X means an oxygen atom, two hydrogen atoms or a hydroxyimino grouping N?OH, R3 and D, which are the same or different, respectively a hydrogen atom, a nitrile radical or a C1 -C4 -alkyl radical or, together, a methylene or ethylene group, E a hydrogen atom or a C1 -C4 -alkyl radical, D and E together meaning a second bond between carbon atoms 1 and 2 or together a methylene group STR3 with R11 in the meaning of a hydrogen atom or a C1 -C8 -alkyl radical, are described as well as their pharmaceutically tolerated addition salts with acids. The new compounds possess valuable pharmacological properties.
