56812-60-3 Usage
Uses
Used in Organic Synthesis:
2-Bromobenzylmagnesium bromide is used as a Grignard reagent for the formation of new carbon-carbon bonds. Its reactivity allows it to react with various electrophiles, such as halides, carbonyl compounds, and epoxides, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-Bromobenzylmagnesium bromide is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its ability to form carbon-carbon bonds makes it instrumental in creating the molecular structures of different drugs.
Used in Natural Product Preparation:
2-Bromobenzylmagnesium bromide is employed as a reagent in the preparation of natural products. Its high reactivity and functional group tolerance contribute to the efficient synthesis of bioactive compounds derived from natural sources.
Used in Advanced Material Synthesis:
In the field of materials science, 2-Bromobenzylmagnesium bromide is used as a building block for the development of advanced materials. Its role in creating carbon-carbon bonds is crucial for the synthesis of materials with specific properties for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 56812-60-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,8,1 and 2 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 56812-60:
(7*5)+(6*6)+(5*8)+(4*1)+(3*2)+(2*6)+(1*0)=133
133 % 10 = 3
So 56812-60-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H6Br.BrH.Mg/c1-6-4-2-3-5-7(6)8;;/h2-5H,1H2;1H;/q-1;;+2/p-1
56812-60-3Relevant academic research and scientific papers
Benzylic Grignard Reagents: Application of (thf = tetrahydrofuran) in Regioselective Grignard Formation and C-O Cleavage in Benzyl Ethers
Gallagher, Michael J.,Harvey, Stephen,Raston, Colin L.,Sue, Rodney E.
, p. 289 - 290 (2007/10/02)
Benzylic Grignard reagents (2)-(4), bearing ortho- and para-halogeno ring substituents, are readily accessible by treating the corresponding benzylic halide with (1) in tetrahydrofuran (thf); o- and p-chloromethyl(methoxymethyl)benzenes with (1) rapidly yield 'di-Grignards' whereas the meta-isomer only affords a mono-Grignard' (5), and bis(methoxymethyl)benzenes slowly undergo C-O cleavage, (6).
An Investigation of the Di-Grignard Approach to Metallabenzocyclobutenes of Group 14
Boer, H. J. R. De,Akkerman, O. S.,Bickelhaupt, F.
, p. 291 - 306 (2007/10/02)
The reactions of 1,2-dihydro-1-magnesabenzocyclobutane (5) with dichlorodimethylsilane (12a), dichloromethylgermane (12b) and dichloromethylstannane (12C) are reported; 1,2-dihydro-1,1-dimethyl-1-silabenzocyclobutene (14a) and 1,2-dihydro-1,1-dimethyl-1-germabenzocyclobutene (14b) were formed in high yields, but the tin analogue was not obtained.Eight-membered ring species, the dimers 17 and 18, were isolated for all three metals.Other products gave useful indications of the probable course of these interesting and complex reactions.
