1190597-99-9Relevant academic research and scientific papers
Aspergillusol A, an α-glucosidase inhibitor from the marine-derived fungus Aspergillus aculeatus
Ingavat, Nattha,Dobereiner, Jeffrey,Wiyakrutta, Suthep,Mahidol, Chulabhorn,Ruchirawat, Somsak,Kittakoop, Prasat
, p. 2049 - 2052 (2009)
A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a gram scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CRI323-04. The tetraol in 4 was identified as erythritol by comparison of the 1H NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited α-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the α-glucosidase from the bacterium Bacillus stearothermophilus.
