1190834-20-8 Usage
Description
(S)-2-fluoro-1-(4-fluorophenyl)ethanol, with the molecular formula C8H8F2O, is a chemical compound that features a fluorinated aromatic ring connected to a fluorinated carbon chain through an alcohol group. (S)-2-fluoro-1-(4-fluorophenyl)ethanol is distinguished by its unique structure and the presence of fluorine atoms, which are known to enhance the biological activity and metabolic stability of molecules in medicinal chemistry and drug discovery. Its stereochemistry and specific properties also render it a valuable tool in asymmetric synthesis and catalysis.
Uses
Used in Pharmaceutical and Agrochemical Industries:
(S)-2-fluoro-1-(4-fluorophenyl)ethanol is utilized as a chiral building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and fluorine substitution contribute to the development of novel and effective compounds with improved pharmacological properties.
Used in Advanced Materials and Fine Chemicals Production:
(S)-2-fluoro-1-(4-fluorophenyl)ethanol also serves as a building block in the production of advanced materials and fine chemicals, where its distinctive structural features and fluorine content play a crucial role in enhancing the performance and properties of the resulting products.
Used in Medicinal Chemistry and Drug Discovery:
The presence of fluorine atoms in (S)-2-fluoro-1-(4-fluorophenyl)ethanol makes it a valuable molecule in medicinal chemistry and drug discovery. The introduction of fluorine often leads to an increase in the biological activity and metabolic stability of bioactive compounds, which is essential for the development of more effective drugs.
Used in Asymmetric Synthesis and Catalysis:
Due to its stereochemistry and specific properties, (S)-2-fluoro-1-(4-fluorophenyl)ethanol is an important tool in asymmetric synthesis and catalysis. It aids in the development of enantiomerically pure compounds, which are crucial for the pharmaceutical industry as they can exhibit different biological activities and reduce potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1190834-20-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,0,8,3 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1190834-20:
(9*1)+(8*1)+(7*9)+(6*0)+(5*8)+(4*3)+(3*4)+(2*2)+(1*0)=148
148 % 10 = 8
So 1190834-20-8 is a valid CAS Registry Number.
1190834-20-8Relevant articles and documents
Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols
Fan, Jiajie,Lin, Xianfu,Peng, Yongzhen,Wang, Anlin,Wu, Qi,Xu, Jian,Xu, Weihua,Yu, Huilei
, (2020/07/24)
A double-enzyme-catalyzed strategy for the synthesis of enantiocomplementary vicinal fluoro alcohols through a one-pot, three-step process including lipase-catalyzed hydrolysis, spontaneous decarboxylative fluorination, and subsequent ketoreductase-catalyzed reduction was developed. With this approach, β-ketonic esters were converted to the corresponding vicinal fluoro alcohols with high isolated yields (up to 92percent) and stereoselectivities (up to 99percent). This new cascade process addresses some issues in comparison with traditional methods such as environmentally hazardous reaction conditions and low stereoselectivity outcome.
Mechanistic investigations of cooperative catalysis in the enantioselective fluorination of epoxides
Kalow, Julia A.,Doyle, Abigail G.
, p. 16001 - 16012 (2011/11/13)
This report describes mechanistic studies of the (salen)Co- and amine-cocatalyzed enantioselective ring opening of epoxides by fluoride. The kinetics of the reaction, as determined by in situ 19F NMR analysis, are characterized by apparent first-order dependence on (salen)Co. Substituent effects, nonlinear effects, and reactivity with a linked (salen)Co catalyst provide evidence for a rate-limiting, bimetallic ring-opening step. To account for these divergent data, we propose a mechanism wherein the active nucleophilic fluorine species is a cobalt fluoride that forms a resting-state dimer. Axial ligation of the amine cocatalyst to (salen)Co facilitates dimer dissociation and is the origin of the observed cooperativity. On the basis of these studies, we show that significant improvements in the rates, turnover numbers, and substrate scope of the fluoride ring-opening reactions can be realized through the use of a linked salen framework. Application of this catalyst system to a rapid (5 min) fluorination to generate the unlabeled analog of a known PET tracer, F-MISO, is reported.
