403-29-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4'-fluoroacetophenone is used as a synthetic intermediate for the development of competitive inhibitors of aromatase, which are essential in the treatment of various hormone-dependent conditions and cancers.
Used in Organic Chemistry:
2-Bromo-4'-fluoroacetophenone is utilized as an organic chemical synthesis intermediate, playing a crucial role in the creation of various organic compounds for different applications across various industries.

InChI:InChI=1/C8H6BrFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 405-99-2 para-fluorostyrene 
• 95895-33-3 1-(bromoethynyl)-4-fluorobenzene 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 350-35-6 1-(1,2-dibromoethyl)-4-fluorobenzene 
• 7542-64-5 α,α-Dibromo-4'-fluoroacetophenone 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 22118-09-8 2-bromoacetyl chloride 
• 462-06-6 fluorobenzene 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 311-08-0 1-ethyl-1-(4-fluoro-phenacyl)-piperidinium; bromide 
• 366-61-0 1-(4-fluoro-phenacyl)-2-methyl-pyridinium; bromide 
• 366-67-6 1-(4-fluoro-phenacyl)-4-methyl-pyridinium; bromide 
• 2992-75-8 2-(4-fluorophenyl)-5-methylindolizine 
• 367-76-0 1-(4-fluoro-phenacyl)-2,6-dimethyl-pyridinium; bromide 
• 636-03-3 3-amino-1-(4-fluoro-phenacyl)-pyridinium; bromide 
• 347-85-3 1-(4-fluoro-phenacyl)-3-hydroxy-pyridinium; bromide 
• 366-65-4 3-fluoro-1-(4-fluoro-phenacyl)-pyridinium; bromide 
• 326-01-2 3-chloro-1-(4-fluoro-phenacyl)-pyridinium; bromide 
• 347-12-6 2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 325-94-0 2-chloro-1-(p-fluorophenacyl)pyridinium bromide 
• 366-60-9 2-bromo-1-(4-fluoro-phenacyl)-pyridinium; bromide 
• 366-64-3 3-bromo-1-(4-fluoro-phenacyl)-pyridinium; bromide 
• 366-66-5 1-(4-fluoro-phenacyl)-3-iodo-pyridinium; bromide 

Relevant academic research and scientific papers

Thiazole ring-containing amide compounds as well as preparation method and application thereof

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Polysubstituted Ligand Framework for Color Tuning Phosphorescent Iridium(III) Complexes

A series of ligands have been synthesized based upon a polysubstituted 2-phenylquinoxaline core structure. These ligands introduce different combinations of fluorine and methyl substituents on both the phenyl and quinoxaline constituent rings. The resultant investigation of these species as cyclometalating agents for Ir(III) gave cationic complexes of the form [Ir(C^N)2(bipy)]PF6 (where C^N = cyclometalating ligand; bipy = 2,2′-bipyridine). X-ray crystallographic studies were conducted on four complexes and each revealed the expected distorted octahedral geometry based upon a cis-C,C and trans-N,N ligand arrangement at Ir(III). Supporting computational studies predict that each of the complexes share the same general descriptions for the frontier orbitals. TD-DFT calculations suggest MLCT contributions to the lowest energy absorption and a likely MLCT/ILCT/LLCT nature to the emitting state. Experimentally, the complexes display tunable luminescence across the yellow-orange-red part of the visible spectrum (λem = 579-655 nm).

Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors

A novel series of phenoxymethybenzoimidazole derivatives (9a-n) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89?μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0?μM). Enzyme kinetic studies on 9c, 9g, and 9m as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzoimidazole and triazole rings of the synthesized compounds to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor.

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.

Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System

A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.

Palladium-Catalyzed Decarboxylative Alkynylation of α-Acyloxyketones by C(sp3)?O Bond Cleavage

Palladium-catalyzed decarboxylative alkynylation of α-acyloxyketones triggered by C(sp3)?O bond cleavage is disclosed. The decarboxylation strategy featuring a neutral reaction condition enabled an unprecedent catalytic alkynylation of a ketone enolate. The reaction was applied to a variety of substrates, giving desired products in good yields. We successfully obtained X-ray crystallography of a new palladium–enolate intermediate that was synthesized by a reaction of [Pd(cod)(CH2TMS)2] with XPhos and α-acyloxyketone at room temperature, indicating facile C(sp3)?O bond disconnection.

Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols

We report herein the development of a S atom transfer process using triethyl phosphite as the S atom acceptor that allows thiols to serve as precursors of C-centered radicals. A range of functionalized and electronically unbiased alkenes including those containing common heteroatom-based functional groups readily participate in this reductive coupling. This process is driven by the exchange of relatively weak S-H and C-S bonds of aliphatic thiols for C-H, C-C, and S-P bonds of the products formed.

Method of utilizing micro channel reactor to prepare pentafluorophenoxyl ketones continuously

The invention discloses a method of utilizing a micro channel reactor to prepare pentafluorophenoxyl ketones continuously. Cheap and easily available styrene and pentafluorophenol are taken as the primary raw materials, two step continuous reactions are carried out in a micro channel reactor to obtain pentafluorophenoxyl ketones, the reaction time is shortened to several minutes from several hours; the product yield is high, the reaction efficiency is obviously enhanced, no any pricy organic catalyst or metal catalyst is needed, the operation is simple, the cost is low, the preparation technology is easy to control, the safety is high, the reaction conditions are mild, and the method can be applied to industrial production.

Novel arylimino thiazole compound, preparation method and uses thereof

The present invention relates to a compound with antibacterial synergy activity, a preparation and uses thereof, particularly to a novel arylimino thiazole compound, a preparation method and uses thereof, and specifically discloses a class of compounds represented by a formula (I) or optical isomers, cis-trans isomers or pharmaceutically acceptable salts thereof, a preparation method and uses thereof. The invention further discloses a pharmaceutical composition containing the compound. The compound of the present invention can effectively enhance the antibacterial activity of antibiotics, andcan be used for treating antibiotic-resistant bacteria. The formula (I) is defined in the specification.