1190848-23-7

Basic information

• Product Name: Fluorobexarotene
• Synonyms: Fluorobexarotene
• CAS NO: 1190848-23-7
• Molecular Formula: C₂₄H₂₇FO₂
• Molecular Weight: 366.4683832
• Mol File: 1190848-23-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Fluorobexarotene(CAS DataBase Reference)
• NIST Chemistry Reference: Fluorobexarotene(1190848-23-7)
• EPA Substance Registry System: Fluorobexarotene(1190848-23-7)

Safety Data

• Hazardous Substances Data: 1190848-23-7(Hazardous Substances Data)

Usage

Uses

Fluorobexarotene is a retinoid X receptor (RXR) agonist, which facilitates β-amyloid clearance across blood-brain barrier; RXR activation has the potential to mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of Alzheimer’s disease.

Upstream product

• 1190848-41-9 methyl 4-(chlorocarbonyl)-2-fluorobenzoate 
• 161796-11-8 3-fluoro-terephthalic acid 4-methyl ester 
• 85070-58-2 methyl 2-fluoro-4-formylbenzoate 
• 74733-29-2 2-methyl-3-hydroxybenzoic acid methyl ester 
• 6683-48-3 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene 
• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 
• 110-03-2 2,5-dimethyl-2,5-hexanediol 
• 1190848-45-3 methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate 
• 1190848-49-7 methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate 

Relevant articles and documents

Synthesis of a new fluorine-18-labeled bexarotene analogue for PET imaging of retinoid X receptor

The reference standard 2-fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)ben-zoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and 2-fluoro-4-methylbenzoic acid in 10 steps with 3% overall chemical yield. The precursor 2-nitro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra-hydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and dimethyl-2-nitroterephthalate in seven steps with 2% overall chemical yield. The target tracer 2-[18F]flu-oro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from its nitro-precursor by the nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC combined with solid-phase extraction (SPE) purification in 20-30% radiochemical yield with 37-370 GBq/μmol specific activity at end of bombardment (EOB).

NOVEL BEXAROTENE ANALOGS

The present invention relates to analogs of bexarotene and methods of use thereof.