1190854-01-3Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors
Truong, Anh P.,Aubele, Danielle L.,Probst, Gary D.,Neitzel, Martin L.,Semko, Chris M.,Bowers, Simeon,Dressen, Darren,Hom, Roy K.,Konradi, Andrei W.,Sham, Hing L.,Garofalo, Albert W.,Keim, Pamela S.,Wu, Jing,Dappen, Michael S.,Wong, Karina,Goldbach, Erich,Quinn, Kevin P.,Sauer, John-Michael,Brigham, Elizabeth F.,Wallace, William,Nguyen, Lan,Hemphill, Susanna S.,Bova, Michael P.,Basi, Guriqbal
, p. 4920 - 4923 (2009)
In this Letter, we report our strategy to design potent and metabolically stable γ-secretase inhibitors that are efficacious in reducing the cortical Aβx-40 levels in FVB mice via a single PO dose.
