1190861-71-2Relevant academic research and scientific papers
PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS
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Page/Page column 75-76, (2019/06/11)
The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode
Eastwood, Paul,González, Jacob,Gómez, Elena,Vidal, Bernat,Caturla, Francisco,Roca, Ramón,Balagué, Cristina,Orellana, Adelina,Domínguez, María
scheme or table, p. 4130 - 4133 (2011/08/10)
The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38α inhibitors. The predicted binding mode was confirmed by X-ray crystallography.
New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
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Page/Page column 24-25, (2009/12/04)
This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
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Page/Page column 38, (2009/10/21)
This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
