870552-47-9

Upstream product

• 40887-80-7 3-bromophenylhydrazine 
• 1190861-71-2 N'-(3-bromophenyl)isobutyrohydrazide 
• 1227417-99-3 1-acetyl-4-bromo-3,3-dimethylindolin-2-one 

Downstream Products

• 1227418-26-9 4-bromo-3,3-dimethylindoline 
• 1227416-10-5 C₂₂H₁₈BrN₅O₂ 

Relevant academic research and scientific papers

NEW PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS

The present invention relates to new compounds of general formula (I) that show dual activity towards α2δ subunit of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit, and to the noradrenaline transporter (NET). The invention is also rel

Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode

The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38α inhibitors. The predicted binding mode was confirmed by X-ray crystallography.

INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP)

The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein ("FABP") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I)