1190927-74-2

Usage

Uses

Used in Agricultural Industry:
2,4-DICHLORO-6,7-DIHYDRO-5H-PYRROLO[3,4-D]PYRIMIDINEHYDROCHLORIDE is used as a pesticide, herbicide, and plant growth regulator for its ability to disrupt the growth of unwanted plants. It is primarily employed in agriculture to control broadleaf weeds in grasses and cereals, ensuring the healthy growth of desired crops.
The selective toxicity of 2,4-DICHLORO-6,7-DIHYDRO-5H-PYRROLO[3,4-D]PYRIMIDINEHYDROCHLORIDE towards plants makes it an effective tool in managing weed populations without causing significant harm to the environment or non-target plant species. Moreover, its relative safety for humans and animals when used according to label instructions adds to its value as a reliable agricultural chemical.

Upstream product

• 635698-34-9 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 903129-71-5 tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 

Downstream Products

• 903129-71-5 tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 

Relevant academic research and scientific papers

Pyrrolidine [3,4-d] pyrimidine derivatives, preparation method and its application

The invention discloses a pyrrolidine[3,4-d]pyrimidine derivative and a preparation method and an application thereof. The pyrrolidine[3,4-d]pyrimidine derivative is an inhibitor of a type I insulin-like growth factor receptor (IGF-1R), and has a good IGF-1R inhibiting function and a good cancer cell proliferation inhibiting function, so that the pyrrolidine[3,4-d]pyrimidine derivative can be taken as a therapeutic agent for treating tumors and relevant diseases.

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

BICYCLIC PYRIMIDINE DERIVATIVES

[wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m + n is 4 or less; R1 represents NR4R5 (wherein R4 and R5 may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl or the like); R2 represents the above Formula (II), Formula (IV) or the like; A represents a single bond, -C(=O)-, -SO2-, -OC(=O)- or the like; and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aralkyl or the like]ψBicyclic pyrimidine derivatives represented by the above Formula (I), or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof, or the like, are provided. These have anti-inflammatory activities or modulation activities on the functions of TARC and/or MDC and are useful for treating and/or preventing a disease which is related to T cells, such as an allergic disease, an autoimmune disease or transplant rejection.