1190931-45-3Relevant academic research and scientific papers
Synthesis and biological study of oxopyrimidines and thiopyrimidines of 2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-carbaldehyde
Ladani,Tala,Akbari,Dhaduk,Joshi
experimental part, p. 104 - 108 (2010/05/19)
2-(2,4-Dichlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (1) was prepared from 2-aminopyridine through multi-step reaction. Compound 1 reacts with different aryl ketones in the presence of catalytic amount of 40% KOH to give (2E)-3-[2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl]-1-arylprop-2-en- 1-ones (2a-j), which on cyclization with urea and thiourea in the presence of basic catalyst like KOH afforded 6-[2-(2,4-dichlorophenyl)imidazo[1,2-a] pyridine-3-yl]-4-aryl-pyrimidin-2(1H)-ones (3a-j) and 6-[2-(2,4-dichlorophenyl) imidazo[1,2-a]pyridine-3-yl]-4-aryl-pyrimidin-2(1H)-thiones (4a-j). The antimicrobial evaluations have been performed for their antibacterial activity and antifungal activities.
