898389-45-2

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 63111-80-8 2-(2,4-dichlorophenyl)-imidazo[1,2-a]pyridine 

Downstream Products

• 1190931-93-1 C₂₂H₁₃Cl₂N₃O₃ 
• 1190931-40-8 C₂₃H₁₆Cl₂N₂OS 
• 1190931-23-7 C₂₄H₁₈Cl₂N₂O 
• 1190931-37-3 C₂₂H₁₃Cl₃N₂O 
• 1190931-38-4 C₂₂H₁₃BrCl₂N₂O 
• 1190930-92-7 C₂₂H₁₄Cl₂N₂O 
• 1190931-20-4 C₂₃H₁₆Cl₂N₂O 
• 1190931-45-3 C₂₂H₁₃Cl₂N₃O₃ 
• 1190931-22-6 C₂₃H₁₆Cl₂N₂O 
• 1175964-89-2 {2-(2,4-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl}methanol 

Relevant academic research and scientific papers

Some Aspects of the Azide-Alkyne 1,3-Dipolar Cycloaddition Reaction

Some peculiar features of two most commonly used catalytic systems (Cul and CuSOVsodium ascorbate) controlling the regioselectivity of 1,3-dipolar cycloaddition of azides to terminal alkynes have been studied. Their potentialities, main disadvantages, and limitations have been demonstrated by a number of examples, including reactions of low-molecular-weight azides and alkynes containing heterocyclic substituents. The possibility of using novel reagents in click reactions is discussed.

Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors

A new series of DPP-4 inhibitors with imidazo[1,2-a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. Based on docking binding model, structural modifications of 2-benzene ring and pyridine moieties of compound 5a led to the identification of compound 5d with 2, 4-dichlorophenyl group at the 2-position as a potent (IC50 = 0.13 μm), selective (DPP-8/DPP-4 = 215 and DPP-9/DPP-4 = 192) and in vivo efficacious DPP-4 inhibitor. Further, molecular docking revealed that compound 5d could retain key binding features of DPP-4 with the pyridine moiety of imidazo[1,2-a]pyridine ring providing an additional π-π interaction with Phe357 of DPP-4. Compound 5d might be a promising lead for further development of novel DPP-4 inhibitor treating T2DM.