1191091-58-3Relevant academic research and scientific papers
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety
Li, Yun-Long,Shi, Eric,Burns, David,Li, Yanlong,Covington, Maryanne B.,Pan, Maxwell,Scherle, Peggy,Friedman, Steve,Metcalf, Brian,Yao, Wenqing
scheme or table, p. 5037 - 5042 (2010/03/31)
A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.
