791834-53-2Relevant articles and documents
AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES
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, (2015/12/18)
The present invention provides a compound of Formula (I) or Formula (II): enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula (I) and (II) are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety
Li, Yun-Long,Shi, Eric,Burns, David,Li, Yanlong,Covington, Maryanne B.,Pan, Maxwell,Scherle, Peggy,Friedman, Steve,Metcalf, Brian,Yao, Wenqing
scheme or table, p. 5037 - 5042 (2010/03/31)
A novel series of carbamates was discovered as potent and selective HER-2 sheddase inhibitors. Significant enhancement in potency and selectivity was achieved through attenuating the P1 moiety, which was conventionally believed to be exposed to solvent.