1191256-01-5Relevant academic research and scientific papers
Second generation synthesis of C27 - C35 Building block of E7389, a synthetic halichondrin analogue
Yang, Yu-Rong,Kim, Dae-Shik,Kishi, Yoshito
supporting information; experimental part, p. 4516 - 4519 (2009/12/07)
A practical method is reported to synthesize E7389 C27-C35 building block 13 from 1,2-O-isopropylidene-α-D-5-deoxyglucurono-6,3-lactone (3). This synthesis relies on two key processes: (1) C34/C35-diol is introduced via asymmetric dihydroxylation with dr
