1191259-51-4

Basic information

• Product Name: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
• Synonyms: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
• CAS NO: 1191259-51-4
• Molecular Weight: 567.734
• Mol File: 1191259-51-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole(1191259-51-4)
• EPA Substance Registry System: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole(1191259-51-4)

Safety Data

• Hazardous Substances Data: 1191259-51-4(Hazardous Substances Data)

Upstream product

• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 158144-52-6 4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 158144-51-5 2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole 

Downstream Products

• 144701-48-4 telmisatran 

Relevant articles and documents

New and improved synthesis of telmisartan: An antihypertensive drug

An improved, cost-effective, and industrially advantageous process suitable for large-scale production of telmisartan 1 has been described. The key steps include Suzuki coupling for the preparation of key intermediate 2-(4'-chloromethyl-biphenyl-2-yl)-4,4

A modification to the synthesis of Telmisartan: An antihypertensive drug

A highly efficient approach to the synthesis of Telmisartan is described. Directed ortho-metalation of 4,4-dimethyl-2-phenyl-4,5-dihydrooxazole provided the key organozinc intermediate for a palladium catalysed biaryl coupling with 3′-(4-bromobenzyl)-1,7′-dimethyl-2′-propyl-1 H,3′ H-2,5′-bibenzo[d]imidazole which was obtained from alkylation of 1,7′-dimethyl-2′-propyl-1 H,3′H-2,5′-bibenzo[d] imidazole. This methodology overcomes many of the drawbacks associated with previously reported syntheses.