3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Base Information

• Chemical Name: 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole
• CAS No.: 1191259-51-4
• Molecular Formula: C₃₇H₃₇N₅O
• Molecular Weight: 567.734
• Mol file: 1191259-51-4.mol

Synonyms:3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Chemical Property of 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

There total 3 articles about 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole (158144-51-5) + 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9) → 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole (1191259-51-4)

Guidance literature:

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; Reflux; Inert atmosphere;

DOI:10.1080/00397910902840850

Reference yield: 85.0%

4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline (158144-52-6) + 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9) → 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole (1191259-51-4)

Guidance literature:

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 55.0%

3'-(4-bromobenzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole + 4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) → 3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole (1191259-51-4)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

3'-(4-bromobenzyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; at 20 - 55 ℃; for 24h; Inert atmosphere;

DOI:10.3184/030823410X12656400473065

upstream raw materials:

2-(4'-chloromethyl-biphenyl-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole

4,5-dihydro-4,4-dimethyl-2-phenoxazole

4,4-dimethyl-2-(4'-methanesulfonyloxymethylbiphenyl-2-yl)oxazoline

Downstream raw materials:

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