119138-87-3

Upstream product

• 88-04-0 4-Chloro-3,5-dimethylphenol 
• 64-19-7 acetic acid 

Downstream Products

• 50343-13-0 1-(3-chloro-6-hydroxy-2,4 dimethyl phenyl) ethanone 
• 855242-08-9 1-(3-chloro-6-hydroxy-2,4-dimethyl-phenyl)-butane-1,3-dione 

Relevant academic research and scientific papers

Lewis acid promoted construction of chromen-4-one and isoflavone scaffolds via regio- and chemoselective domino Friedel-Crafts acylation/Allan-Robinson reaction

A facile and efficient synthesis of chromen-4-one and isoflavone frameworks is achieved by the domino C-acylation/O-acylation/aldolization sequence. This operationally simple one-pot elegant strategy provides structurally unique chromen-4-ones and isoflavones directly from phenols via concomitant formation of multiple C-C and C-O bonds in a single operation. The outcomes of the buttressing effect, substituent dependence, and catalyst and solvent specificity during the course of the Friedel-Crafts acylation reactions are demonstrated and supported by fitting experiments.