1191545-52-4

Upstream product

• 79-37-8 oxalyl dichloride 
• 887307-13-3 1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid 

Downstream Products

• 887307-14-4 5-[(2-chloro-4-fluorophenyl)acetyl]-1-(2,6-dichlorophenyl)pyridin-2(1H)-one 

Relevant academic research and scientific papers

NITROGENOUS HETEROCYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF

The present invention relates to a compound that has p38 MAP kinase inhibitory activity useful as drug medicine, represented by the general formula (I) : wherein all the symbols are as defined in the description, or itssalt, N-oxide or solvate, or a prodrug thereof. Further, there are provided a process for producing the same and usage thereof. The compound of the general formula (I) has a p38 MAP kinase inhibory activity and is useful for the prevention and/or treatment of diseases in which an abnormal production of cytokine, such as inflammatory cytokine or chemokine, or an over-reaction thereto would be instrumental in the cause and aggravation of pathologic condition thereof, namely, cytokine-mediated diseases, for example, inflammatory diseases, respiratory diseases, circulatory diseases, central nervous diseases, etc.