119162-75-3Relevant academic research and scientific papers
Evolution of a New Class of VEGFR-2 Inhibitors from Scaffold Morphing and Redesign
Mainolfi, Nello,Karki, Rajeshri,Liu, Fang,Anderson, Karen
, p. 363 - 367 (2016)
Anti-VEGF therapy is a clinically validated treatment for age-related macular degeneration (AMD). We have recently reported the discovery of oral VEGFR-2 inhibitors that are selectively distributed to the ocular tissues. Herein we report a further development of those compounds and in particular the validation of the hypothesis that aminoheterocycles such as aminoisoxazoles and aminopyrazoles could also function as effective "hinge" binding moieties leading to a new class of KDR (kinase insert domain containing receptor) inhibitors.
