119162-48-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-NITRO-PHENYL)-ISOXAZOL-5-YLAMINE is used as a key intermediate in the synthesis of various drugs for its unique structural features that can be leveraged to develop new therapeutic agents with specific biological activities.
Used in Agricultural Industry:
In the agricultural sector, 3-(4-NITRO-PHENYL)-ISOXAZOL-5-YLAMINE is utilized as a component in the creation of agrochemicals, potentially contributing to the development of novel pesticides or other crop protection products.
Used in Medicinal Chemistry Research:
3-(4-NITRO-PHENYL)-ISOXAZOL-5-YLAMINE serves as a valuable building block in medicinal chemistry for the exploration and development of innovative therapeutic agents, capitalizing on its reactivity and structural attributes to engineer compounds with desired pharmacological properties.

InChI:InChI=1/C9H7N3O3/c10-9-5-8(11-15-9)6-1-3-7(4-2-6)12(13)14/h1-5H,10H2

Upstream product

• 3383-43-5 (4-Nitrobenzoyl)acetonitrile 
• 151-50-8 potassium cyanide 
• 71707-45-4 2-chloro-3-(4-nitrophenyl)acrylonitrile 

Downstream Products

• 119162-75-3 3-(4-aminophenyl)isoxazol-5-amine 

Relevant academic research and scientific papers

The study of reactions of α-chlorocinnamonitriles with hydroxylamine

The E-isomers of α-chlorocinnamonitriles react with hydroxylamine to give a mixture of isomeric aminoisoxazoles, while the Z-isomers yield 3-aryl-2-chloroacrylamide oximes.

Reactions of 5-Aminoisoxazoles with α-Diazocarbonyl Compounds: Wolff Rearrangement vs N-H Insertion

A highly chemoselective reaction between 5-aminoisoxazoles and α-diazocarbonyl compounds has been described. Both Wolff rearrangement and N-H insertion products can be obtained selectively by the judicious choice of reaction conditions. In the case of the

Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions

A one-pot reaction to synthesize functionalized 2H-azirines through visible-light-mediated ring contraction and olefin metathesis of isoxazoles is described. Hoveyda-Grubbs II catalyst was found to function as a photocatalyst for these transformations, al

A modified procedure for the synthesis of 5-amino-3-arylisoxazoles and their reactions with tetrasulfur tetranitride antimony(V) chloride complex (S4N4·SbCl5): Novel synthesis of 3-aryl-1,2,5-thiadiazole-4-carboxamides

Dropwise addition of α-bromo ketoximes to a solution of KCN in MeOH at room temperature gave 5-amino-3-arylisoxazoles in moderate to good yields. Treatment of the isoxazoles prepared with tetrasulfur tetranitride antimony (V) chloride complex (S4N4·SbCl5) in toluene at 100°C afforded novel 3-aryl-1,2,5-thiadiazole-4-carboxamides.