119189-70-7

Usage

Uses

Used in Pharmaceutical Industry:
Bis-PEG6-acid is used as a PROTAC linker for the synthesis of protein degrader molecules, which are designed to modulate cellular pathways and target specific proteins for degradation. This application is crucial for the development of novel therapeutic strategies in various diseases.
Used in Drug Delivery Systems:
Bis-PEG6-acid is used as a component in the design of drug delivery systems, where its hydrophilic PEG spacer can improve the solubility and bioavailability of therapeutic agents. This enhances the overall efficacy and pharmacokinetics of the drug delivery system.
Used in Chemical Synthesis:
Bis-PEG6-acid is used as a versatile building block in chemical synthesis, particularly for the creation of conjugates and biocompatible materials. Its reactive carboxylic acid groups facilitate the formation of stable amide bonds with primary amine-containing molecules, allowing for the development of a wide range of applications in the chemical and materials science fields.

Upstream product

• 4792-15-8 Pentaethylene glycol 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 119189-71-8 3,6,9,12,15,18-hexaoxaeicosanedinitrile 

Relevant academic research and scientific papers

GLUCAGON-LIKE PROTEIN-1 RECEPTOR (GLP-1R) AGONIST COMPOUNDS

The present invention provides GA targeting compounds which comprise GA targeting agent-linker conjugates linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.

Intramolecular End-to-End Reactions of Photoactive Terminal Groups Linked by Poly(oxyethylene) Chains

The triplet-sensitized photochemical reaction using a series of poly(oxyethylene) chains with a pair of photoactive terminal groups, dibenzazepine (DBA) chromophores (DBA-COCH2CH2(OCH2CH2)nOCH2CH2CO-DBA, n=0-10) was examined.The photoirradiation of bichromophoric compounds caused either intra- or intermolecular reactions.These reactions were kinetically analyzed by two different methods: the measurement of deactivation processes of the reaction intermediates (excited triplet state of DBA) by nanosecond laser photolysis and the quantitative analysis of the reaction products by GPC.The intramolecular deactivation rate constant, kintra, showed a remarkable chain-length dependence; the maximum kintra value appeared at n=5 and it was found to be 5.9X104 s-1.On the other hand, the intramolecular cyclization rate also depends on the chain length; the maximum quantum yield, φintrad, was given at n=7 (φintrad=0.51).The chain length for the maximum cyclization yield shifted slightly to the longer region than that for the maximum kintra value due to the restriction of the terminal structure (anti-configuration).The results obtained for this reaction system are compared with those obtained for the previously reported polymethylene system and the effect of chain flexibility on the intramolecular ring-closure reaction is discussed.