1191918-78-1Relevant articles and documents
Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists
Andrews, Mark D.,Green, Martin P.,Allerton, Charlotte M.N.,Batchelor, David V.,Blagg, Julian,Brown, Alan D.,Gordon, David W.,McMurray, Gordon,Millns, Daniel J.,Nichols, Carly L.,Watson, Lesa
scheme or table, p. 5346 - 5350 (2010/05/19)
This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A an