1191950-75-0Relevant academic research and scientific papers
Palladium-catalyzed three-component cascade arylthiolation with aryldiazonium salts asS-arylation sources
Li, Jianxiao,Tang, Hao,Lin, Zidong,Yang, Shaorong,Wu, Wanqing,Jiang, Huanfeng
, p. 4071 - 4078 (2020/06/09)
A novel and efficient palladium-catalyzed three-component cascade cyclization/arylthiolation has been developed for the assembly of diverse 3-sulfenylindole and 3-sulfenylbenzofuran derivatives from 2-alkynylamines and 2-alkynylphenols, aryldiazonium salts, and Na2S2O3under aerobic conditions with PEG-200 as an environmentally benign medium. The current study features exceptional functional group tolerance without additional ligands, oxidants or silver salts, and eco-friendly mild reaction conditions. The ionic liquid [C2OHmim]Cl plays a crucial role in this protocol as an environmentally friendly additive. Notably, this procedure represents the first example of the use of aryldiazonium salts as directS-arylation sources in this type of chemical transformation.
A process for the preparation of substituted benzofuran derivatives (by machine translation)
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Paragraph 0046; 0047; 0048; 0049, (2016/10/17)
The invention belongs to the technical field of organic chemical industry, in particular to a multi-substituted benzofuran derivatives preparation method. The method for coupling-connected in series with a pot, the end-based hydrocarbon, halogenated phenol derivatives with disulfide or b selenide reaction, the amino acid as a additive, copper salt as a catalyst, under the conditions of the alkali is added, reaction is carried out in an organic solvent in preparing multi-substituted benzofuran derivatives. This invention does not have to adopt the expensive palladium catalyst of environmental pollution, relatively mild reaction conditions, simple process, the operability is strong, has industrial application prospect. (by machine translation)
Assembly of 3-Sulfenylbenzofurans and 3-Sulfenylindoles by Palladium-Catalyzed Cascade Annulation/Arylthiolation Reaction
Li, Jianxiao,Li, Chunsheng,Yang, Shaorong,An, Yanni,Wu, Wanqing,Jiang, Huanfeng
, p. 2875 - 2887 (2016/04/26)
A novel and efficient palladium-catalyzed cascade annulation/arylthiolation reaction has been developed to afford functionalized 3-sulfenylbenzofuran and 3-sulfenylindole derivatives in moderate to good yields from readily available 2-alkynylphenols and 2
A green and efficient approach for the synthesis of 3-chalcogen Benzo[b]Furans via i 2-mediated cascade annulation reaction of 2-alkynylanisoles at room temperature in water
Han, Jiang-Sheng,Shao, Yin-Lin,Zhang, Xiao-Hong,Zhong, Ping
, p. 1599 - 1610 (2013/10/21)
An efficient and green aqueous protocol to access 3-chalcogen benzo[b]furan derivatives has been developed. The reaction can proceed via I 2-mediated intramolecular annulation reaction of 2-alkynylanisoles with diaryl disulfides (diselenides) i
Metal-free synthesis of 3-chalcogen benzo[b]furans via an iodine-mediated electrophilic cyclisation of 2-alkynylanisoles
Xu, Mei,Zhang, Xiao-Hong,Zhong, Ping
scheme or table, p. 6800 - 6804 (2012/01/02)
An efficient and metal-free method was developed to synthesize 3-chalcogen benzo[b]furans via the iodine-mediated electrophilic cyclisation of 2-alkynylanisoles with disulfides or diselenides. In the presence of I 2, various 3-sulfenylbenzofura
PdCl2-promoted electrophilic annulation of 2-alkynylphenol derivatives with disulfides or diselenides in the presence of iodine
Du, Hui-Ai,Zhang, Xing-Guo,Tang, Ri-Yuan,Li, Jin-Heng
experimental part, p. 7844 - 7848 (2010/01/16)
(Chemical Equation Presented) An efficient synthesis of 3-chalcogen-benzo[b]furans via palladium-promoted annulation reactions of 2-alkynylphenol derivatives with disulfides or diselenides and iodide has been developed. In the presence of I2 an
