119197-24-9

Upstream product

• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 149508-60-1 2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 136000-11-8 (Z)-2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 136000-12-9 (E)-2-phenyl-3-ethylthio-4,4,4-trifluoromethyl-but-2-en-1-al 
• 133205-47-7 3-phenyl-4-(trifluoromethyl)quinoline 
• 14468-40-7 2-(trifluoromethyl)-1,3-benzothiazole 
• 133205-46-6 3-phenyl-2-trifluoromethyl-1,5-benzothiazepine 
• 910618-49-4 α-phenyl-2-(trifluoromethyl)thiazolidine-2-acetaldehyde 
• 149508-58-7 6-phenyl-7-trifluoromethyl-2,3-dihydro-1,4-thiazepine 
• 167279-18-7 ethyl 5-(trifluoromethyl)-4-phenylthiophene-2-carboxylate 
• 185389-51-9 (E)-3-phenyl-4-diethylamino-1,1,1-trifluorobut-3-en-2-one 

Relevant academic research and scientific papers

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally bioavailable amino acid-based S1P1 agonists represented by 7. Many of the new

NOVEL THIOPHENE DERIVATIVES

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

Preparation of pyrrole-2-carboxylates with electron-withdrawing groups at the 4-position

Reaction of α-trifluoromethyl, α-cyano, and α-ethoxycarbonyl alkenyl sulfones with ethyl isocyanoacetate in the presence of a base gave 4- substituted pyrrole-2-carboxylates in moderate to good yields.

Reactivity of β-(trifluoromethyl) acroleins towards primary alkyl (or aryl) amines: synthesis of trifluoromethyl)-1-aza-1,3-dienes and secondary (trifluoromethyl) allylamines

Vilsmeier's reaction on trifluoroketones leads to β-chloro-β(trifluoromethyl)acroleins.The addition of primary alkyl- or aryl-amines to these acroleins leads in all cases to the formation of stable (trifluoromethyl)-1-aza-1,3-dienes which can be transform

Synthesis of γγγ-trifluorocarbonyl compounds

γγγ-Trifluorocarbonyl compounds are easily obtained in a good yield by introduction of the 1,1,1-trifluoroethyl moiety (CF3-CH2-) on the α-methylene group of a ketone.

A new and efficient synthesis of trifluoroalkyl aldehydes or ketones from the same starting material

4,4,4-trifluoroacroleines 2 have been converted specifically by tributyl tin hydride to aldehyders 3 or ketones 4, according to the catalyst and conditions employed.