1192-81-0

Basic information

• Product Name: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE
• Synonyms: 1,2,4-oxadiazole, 5-(chloromethyl)-3-methyl-;5-(chloromethyl)-3-methyl-1,2,4-oxadiazole(SALTDATA: FREE);-3-methyl-1,2,4-oxadiazole
• CAS NO: 1192-81-0
• Molecular Formula: C₄H₅ClN₂O
• Molecular Weight: 132.55
• Mol File: 1192-81-0.mol

Chemical Properties

• Boiling Point: 211.669 °C at 760 mmHg
• Flash Point: 81.815 °C
• Appearance: /
• Density: 1.291 g/cm³
• Vapor Pressure: 0.262mmHg at 25°C
• Refractive Index: 1.483
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: -1.10±0.32(Predicted)
• CAS DataBase Reference: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(1192-81-0)
• EPA Substance Registry System: 5-(CHLOROMETHYL)-3-METHYL-1,2,4-OXADIAZOLE(1192-81-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1192-81-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole serves as a crucial intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole is utilized as an intermediate for the production of agrochemicals, contributing to the creation of effective pesticides and other agricultural products.
Used in Antimicrobial Applications:
5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole is recognized for its antimicrobial properties, making it a potential candidate for use in the development of antimicrobial agents to combat resistant bacterial strains.
Used in Antiviral Applications:
5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole's antiviral potential positions it as a candidate for the development of antiviral medications, which could be instrumental in treating a range of viral infections.
Used in Anticancer Applications:
5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole's anticancer properties are under investigation, with the aim of developing it as a component in cancer treatment regimens, potentially offering new therapeutic options for cancer patients.

InChI:InChI=1/C4H5ClN2O/c1-3-6-4(2-5)8-7-3/h2H2,1H3

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Downstream Products

• 625446-01-7 1-cyclopentyl-3-{4-[(3-methyl-1,2,4-oxadiazol-5-yl)methoxy]phenyl}propan-1-one 
• 74704-86-2 2,6-diethyl-N-(3'-methyl-1',2',4'-oxadiazol-5'-yl-methyl)-aniline 
• 1235840-72-8 1-methyl-6-(4-(2-(1-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)piperidin-4-yl)-ethoxy)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile 
• 1354198-41-6 2-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 
• 1411980-31-8 2-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-7-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one 
• 1411981-26-4 3-((3-methyl-1,2,4-oxadiazol-5-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one 
• 14374-19-7 3-methyl-5-(diethoxyphosphorothioylthiomethyl)-1,2,4-oxadiazole 

Relevant articles and documents

Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.

Substituted triazolo-pyridazine derivatives as ligands for GABA receptors

Substituted triazolo-pyridazine derivative compounds represented by wherein the variables are disclosed herein are selective ligands for GABA-A receptors, particularly for the α2 and/or α3 subunits.

Substituted oxadiazoles and their use as corn root worm insecticides

A method for killing corn root worms by applying to the soil habitat of the root worms an insecticidal amount of the compound of the formula STR1 wherein R1, R2 and R3 are alkyl of 1 to 4 carbon atoms; and X, Y, Z and V are sulfur or oxygen.